World number one Carlos Alcaraz faces a potential quarter-final clash with old foe Jannik Sinner in his US Open title defence, and American Coco Gauff is on a collision course with defending champion Iga Swiatek on the women's side.
Third seed Alexander Zverev produced a near-flawless display to outclass former champion Holger Rune 6-3 7-6(4) on Saturday and return to the Paris Masters final after a gap of four years.
The two cases shocked the tennis world with many fuming at how they were handled by the authorities.
Jannik Sinner will hope to block out a rocking home crowd on Sunday when he faces Taylor Fritz in the US Open final at Flushing Meadows, where the 12th seed will be bidding to become the first American man in 21 years to win a Grand Slam singles title.
Rafael Nadal continued his perfect run on the North American hardcourts taming Czech Tomas Berdych 7-5, 7-6 (4) at the Western and Southern Open on Saturday to setup a final showdown with big-hitting American John Isner.
Simona Halep ended Beatriz Haddad Maia's dream run in Toronto
Need to raise game against Djokovic, says Medvedev ahead of US Open final
A crowd favourite for her creative playing style, Ons Jabeur rolls into her second straight Grand Slam championship match brimming with confidence, with lessons learned from her heartbreaking loss at the All England Club to Kazakhstan's Elena Rybakina.
The Indian ace beat Anna-Lena Groenefeld 6-4, 6-3 in the first round of the Western and Southern Financial Group Women's Open
World number one Serena Williams was at her lethal best as she crushed Romanian Simona Halep 6-0, 6-4 to romp into the semi-finals of the Western and Southern Open on Friday.
Medvedev on everyone's US Open radar after first round rout
Nick Kyrgios has been fined $113,000 by the ATP for arguing with the chair umpire and smashing two rackets during his second-round loss at the Cincinnati Masters.
Rafael Nadal returns to the US Open for the first time in three years short of match practice and with big question marks about his fitness but few people will dismiss the Spaniard's chances of claiming a record-extending 23rd Grand Slam title.
Novak Djokovic enjoyed a stress-free return to US competition following a two year absence
Federer's pullout from Cincinnati hands number one spot to the Spaniard
Alcaraz, winner of the last two Grand Slams at Roland Garros and Wimbledon, had made it to at least the quarter-final stage at every major in which he has competed since winning the US Open two years ago.
Naomi Osaka has four major titles under her belt but the second round at Flushing Meadows, Wimbledon and Roland Garros was as good as it got this year for the Japanese 26-year-old, who exited the Australian Open in the first round.
Second seed Daniil Medvedev will launch his bid to win his first major title against veteran Frenchman Richard Gasquet.
Novak Djokovic, Andy Murray, Rafael Nadal and Roger Federer all picked up third round wins at the Western and Southern Open on Thursday to set up a star-studded last eight in Cincinnati.
India's Sania Mirza and her women's doubles partner Barbara Strycova crashed out of the BNP Paribas Open after going down in straight sets in the quarter-finals at Indian Wells.
World No 1 Serena Williams won a tense battle of U.S. Open champions by beating Australia's Samantha Stosur 7-6(7), 7-6(7) on Wednesday to reach the third round of the Western and Southern Open in Cincinnati.
They now face eighth-seeded pair of Canada's Vasek Pospisil and local boy Jack Sock, whom they beat 6-1, 6-4 in Paris.
Sania Mirza and Monica Niculescu stunned Wimbledon doubles champions Vania King and Yaroslava Shvedova to storm into the quarter-finals of the the Western and Southern Financial Group Women's Open in Cincinnati.
World number one Roger Federer warmed up for the defence of his U.S. Open title in perfect fashion as he beat fourth seed Novak Djokovic 6-1, 7-5 to win the Cincinnati Masters on Sunday.
A summary of Tuesday's action at the US Open.
Spain's Tommy Robredo shocked world number one Novak Djokovic 7-6(6), 7-5 on Thursday to move into the quarter-finals of the Western and Southern Open in Cincinnati.
Osaka's hardcourt swing leading into the US Open has been rough
Raducanu stormed into the third round of the Cincinnati Open
Williams has just one professional tournament remaining before she drops the curtain on her historic career
Novak Djokovic begins his hunt for a fifth Flushing Meadows crown when he meets Moldovan Radu Albot
'Serena must be prepared to live with it and say goodbye even in the face of defeat'
The Scotsman doesn't expect to win US Open this year
Roger Federer survived a scratchy performance to beat Marcos Baghdatis 7-6, 7-5 to reach the quarter-finals.
Former US Open champion Svetlana Kuznetsova has joined a growing list of players who have decided not to play in this year's tournament due to concerns over the COVID-19 pandemic.
The five top contenders for the women's title at the Australian Open, which starts on Monday.
Images from Day 3 of the US Open, at Flushing Meadows, New York.
Roger Federer cruised to a 6-4, 6-4 win over Peter Gojowczyk in his first appearance since losing in the Wimbledon quarter-finals.
India's campaign ended at the Cincinnati Masters tennis tournament after Sania Mirza and Cara Black went down to Anabel Medina Garrigues of Spain and Kazakhstan's Yaroslave Shvedova in their women's doubles second round match.
Serena Williams was included on the entry list for the US Open on Wednesday along with fellow former champion Novak Djokovic, who will not be able to compete due to his refusal to be vaccinated against COVID-19.
John Peers and Storm Sanders became the first Australians since 2001 to claim the US Open mixed doubles title with a 4-6, 6-4, 10-7 win over Belgian Kirsten Flipkens and France's Edouard Roger-Vasselin on Saturday.